One of the dental-related incidents was documented in the report:ĭuring IVS procedure pt re-sedated. Of the 1,529 reports only two were attributed to dentistry. Of the 498 incidents, three patients died, 48 incidents resulted in moderate harm to patient and the remaining 447 caused low or no harm to the patients. The report documented 498 incidents of adult patients being given midazolam during the period from November 2004 to November 2008. The National Patient Safety Agency (NPSA)'s rapid response report (RRR), Reducing risk of overdose with midazolam injection in adults, 1 reviewed 1,529 medication-related patient safety incident reports received by the Reporting and Learning System (RLS) where the words midazolam or flumazenil (or related terms) were contained in the report. Each case should be individually considered, justified and documented within the patient's clinical record.

The audit has highlighted distinct indications for the post-operative use of flumazenil in specifically selected cases. No cases required flumazenil for the emergency treatment of respiratory depression.Ĭonclusions The results of the audit confirmed the safe and appropriate use of midazolam for conscious sedation within the Department of Sedation and Special Care Dentistry at Guy's Hospital and demonstrated that flumazenil use was low and in accordance with current best practice. Results Four hundred and fifty-three patients were sedated with midazolam. Method All clinical staff completed the data capture proforma when flumazenil was administered to a patient after sedation with midazolam. Subjects Patients sedated with midazolam for dental treatment. Objective To investigate the use of flumazenil after midazolam-induced conscious sedation.ĭesign and setting A prospective audit was carried out in the Department of Sedation and Special Care Dentistry at Guy's Hospital, King's College, London, 2009.

Midazolam antidote